The anime should be more like Mononoke, the TV series not PRINCESS Mononoke, where there are story arcs and in each arch the story changes. I also don't think it should be a long anime. Perhaps just one season at very most of 15 episodes. The story arcs would be 3-4 episodes long, and the last arch should be a bit opened ended, just like both games are.
By doing this, it allows a little more freedom with story line and can introuce new characters as well as old ones. There could be a story arch for NiD and another for JOD and none of them ever have to be in a time line.
I think the anime should be drawn with a different style in mind. Should keep tot he dreaminess of the NiGHTS games and not really conform much. I believe the music should be in a style much like Tomoko Sasaki's but I wouldn't mind hearing some variation along with it, like little jingle and tines. I think it should be orchestrated and not so much band music.
Anime would NOT be dubbed or int he care of 4Kids. Hey, they could do Sonic that's fine but don't touch NiGHTS!!
Guy who voiced Wizeman would still play Wizeman because he is freaking awesome Wizeman voice. However, personally I would change both Reala and NIGHTS voice actors for every story arch... as with JOD they spoke with accents because the kids did, right? So NiGHTS and Reala can have some variation. I awnna hear German Reala, Damn it!!
And the Anime would be released in the States with DVDs that allowed Japanese audio tracks.
I wish I could make a NiGHTS Anime or be a part of it.